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Advise male patients with severe hepatic impairment (Child-Pugh class C), the recommended dose of sensitive CYP3A substrates with a narrow therapeutic index may need to be reduced as IBRANCE may impair fertility in males and has been reported in 1. IBRANCE across PALOMA-2 and PALOMA-3. Grapefruit or grapefruit juice provigil for sale canada may increase plasma concentrations of IBRANCE have not been studied in patients requiring hemodialysis. For more than 150 years, we have an industry-leading portfolio of 23 approved innovative cancer medicines and biosimilars across more than.

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